The Science Centre on Morgan Thomas Lane, off Kintore Avenue, is where the majority of the Museum's scientists work. It is also where most of the Australian Polar, Biological Sciences, Mineral Sciences, Palaeontology and Information Resources collections are housed. For these reasons it forms a critical part of the activities of the South Australian Museum, despite being largely tucked away from the public gaze.
Access to the basement of the Science Centre is currently restricted because this area of the building is being used for other purposes during the reintegration of the Entomology Collection into new, purpose-built facilities.
Presently, the most accessible part of the Science Centre is the Mawson Centre which has a display of artefacts, maps and photographs about Sir Douglas Mawson's life, research and achievements from the Mawson Collection.